Individuals with MTHFR gene mutations have a lowered ability to produce the key anti-oxidant glutathione.  Glutathione is critical for detoxification and immune modulation.  These individuals are at a much greater risk for developing auto-immune or chronic inflammatory diseases (17).

They need extra methylation support nutrients such as methyl-folate, methyl-B12, zinc, magnesium, riboflavin and B6 (18).